PD-1|PD-L1-IN1
PD-1|PD-L1-IN1
CAS: 1818314-88-3
Molecular Formula: C36H33ClN2O7
PD-1|PD-L1-IN1 - Names and Identifiers
PD-1|PD-L1-IN1 - Physico-chemical Properties
| Molecular Formula | C36H33ClN2O7 |
| Molar Mass | 641.11 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Boling Point | 817.5±65.0 °C(Predicted) |
| Solubility | DMSO : 125 mg/mL (194.97 mM; Need ultrasonic) |
| pKa | 2.03±0.40(Predicted) |
| Storage Condition | -20°C |
| Physical and Chemical Properties | Bioactive BMS-1166 is a new and effective inhibitor of PD-1/PD-L1 interaction with IC50 of 1.4 nM. |
| In vitro study | BMS-1166 was less toxic to the cell lines tested, preventing the interaction of soluble PD-L1 with the PD-1 receptor expressed on the cell surface. BMS-1166 attenuated PD-L1 inhibition of T cell receptor-mediated T lymphocyte activation. |
PD-1|PD-L1-IN1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.56 ml | 7.799 ml | 15.598 ml |
| 5 mM | 0.312 ml | 1.56 ml | 3.12 ml |
| 10 mM | 0.156 ml | 0.78 ml | 1.56 ml |
| 5 mM | 0.031 ml | 0.156 ml | 0.312 ml |
Last Update：2024-01-02 23:10:35
PD-1|PD-L1-IN1 - Introduction
PD-1 | PD-L1-IN1 is an organic compound with the chemical formula C14H11N3O3S. The following is a description of the nature, use, method and safety information of PD-1 | PD-L1-IN1:
Nature:
PD-1 | PD-L1-IN1 is a solid, room temperature for white crystal. It has a melting point of 198-199 ° C. And is insoluble in water and slightly soluble in organic solvents.
Use:
PD-1 | PD-L1-IN1 is a kind of drug material, which is widely used in cancer treatment research. It can be used as a promising anticancer drug candidate with the potential to inhibit tumor growth, especially for breast cancer and colorectal cancer.
Preparation Method:
PD-1 | The preparation method of PD-L1-IN1 is generally realized by chemical synthesis. Specifically, a commonly used synthetic route is to obtain PD-1 PD-L1-IN1 by reacting BMS-275291 with sulfuryl chloride under appropriate reaction conditions.
Safety Information:
Nature:
PD-1 | PD-L1-IN1 is a solid, room temperature for white crystal. It has a melting point of 198-199 ° C. And is insoluble in water and slightly soluble in organic solvents.
Use:
PD-1 | PD-L1-IN1 is a kind of drug material, which is widely used in cancer treatment research. It can be used as a promising anticancer drug candidate with the potential to inhibit tumor growth, especially for breast cancer and colorectal cancer.
Preparation Method:
PD-1 | The preparation method of PD-L1-IN1 is generally realized by chemical synthesis. Specifically, a commonly used synthetic route is to obtain PD-1 PD-L1-IN1 by reacting BMS-275291 with sulfuryl chloride under appropriate reaction conditions.
Safety Information:
Last Update：2024-04-09 01:59:58
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